SBIR 95-1 SOLICITATION
SOLID STATE LIGHT SOURCE FOR IRRIDATING AUTOLOGOUS BONE MARROW GRAFTS
Future long range space missions will require innovative emergency medical procedures and
techniques for the treatment of serious injuries in space. Photothearpy and
Photochemotherapy have disclosed advances in Photodynamic therapy research that will lead
the way to innovative treatment for Prolonged Immune Suppression, Osteoprosis during
space flight and trauma burn treatment. Autologous bone marrow transplants are a method of
Extracorporeal Photochemotherapy that rids marrow grafts of harmful tumor cells. patients
are administered a photosensitive drug which attaches itself to the harmful tumor cells, then
the bone marrow is extracted from the body. Irradiating the drug causes it to activate,
terminating the tumor cells. This method of bone marrow purging has shown great promise
as a treatment for cancer. However, issues have surfaced about the high cost of replacement
lamps, heat dissipation, and the broad band light source currently being used. Recent
advancements in semiconductor technology , developed for NASA's long term space
missions, has led to the development of an economical LED-based reusable system that
could be designed to meet the requirements for light assisted purging of marrow grafts.
Resulting in reduced cost and improved availability of this life saving therapy to a greater
number of patients.
Potential Commercial Applications:
QDI is confident in the market potential of a commercially viable LED-based lighting system
that could be used to activate a photosensitive dyes, such as Merocynanine 540,for for bone
marrow purging. In addition QDI intends to aggressively pursue the sale of the LED source in
other areas that will include the use of other photosensitive dyes to treat diseases such as,
Psoriasis, vitiligo, herpetic skin and eye lesions, selected solid tumors, and, more recently, the
treatment of warts, graft-vs.-host diseases (GvHD), cutaneous T cell lymphoma, Chronic
lymphocytic leukemia, Rheumatoid arthritis, Multiple sclerosis, pemphigus, and progressive
systemic sclerosis, the prevention of graft rejection and GvHD in recipients of tissue or organ
transplants, and the inactivation of viruses in blood products.
Name and Address of Offeror:
QUANTUM DEVICES, INC.
112 ORBISON STREET
BARNEVELD, WI 53507
Small Business Innovation Research Program (SBIR) &
Small Business Technology Transfer Program (STTR) Programs
Electronic Management System (EMS)
National Aeronautics and Space Administration (NASA)
The SBIR/STTR EMS site is maintained by Steve
Hu, Hughes STX.
For comments and questions, contact
Updated: Feb. 7, 1996