An Adaptive Filter Approach to Auto-Calibration of Spectroscopic Instruments
An Adaptive Filter Approach to Auto-Calibration of
Biotronics Technologies, Inc.
W226 N555B East Mound Drive
Waukesha, WI 53186
Kenneth J. Schlager (414-896-2650)
Spectroscopic instruments used in chemical analysis have made
significant advances in "re-agentless" quantitative assays
performed in industrial, environmental, medical, and space
applications. These instruments are noninvasive because they
perform measurements nondestructively and without interference to
the process. While progress has been particularly noteworthy in
the near infrared spectral region, quantitative spectrometric
analysis has been handicapped by the continuing need for complex
calibration procedures. Typical regimens require 50 to 200 labeled
samples in "learning sets" to calibrate each instrument. These
calibration procedures must also be repeated periodically to
reflect changes in process characteristics or instrument drift.
The goal of this project is to develop a new approach to
spectroscopic instrument calibration that does not require
multiple labeled samples. This new technique is based on adaptive
filter technology that allows the instrument to continually re-
adjust its calibration in the field. The only exogenous input
requirement is a standard spectrum of each sample of interest.
This innovation in calibration promises to greatly expand the
applications of many forms of spectrometry in quantitative
Potential Commercial Application:
Potential Commercial Applications: Adaptive spectroscopic
calibration will greatly expand the market for on-line and
noninvasive near-infrared absorption, ultraviolet-visible
absorption, fluorometric, and atomic-emission spectrometry in
environmental, medical, industrial, and space applications.