NASA SBIR 2019-I Solicitation

Proposal Summary

 19-1- H3.03-3598
 Microbial Monitoring and Control for Spacecraft Cabins
 Zeteo Space Environment Microbial Monitoring System (zSEMMS)
SMALL BUSINESS CONCERN (Firm Name, Mail Address, City/State/Zip, Phone)
Zeteo Tech, Inc.
6935 Warfield Avenue
Sykesville, MD 21784- 7454
(410) 979-1190

Principal Investigator (Name, E-mail, Mail Address, City/State/Zip, Phone)

Mr. Thomas McCreery
2790 S Mario Ranch Ln Tucson, AZ 85730 - 1547
(520) 664-4999

Business Official (Name, E-mail, Mail Address, City/State/Zip, Phone)

Dr. Charles Call
6935 Warfield Avenue Sykesville, MD 21784 - 7454
(505) 459-2156
Estimated Technology Readiness Level (TRL) :
Begin: 5
End: 6
Technical Abstract (Limit 2000 characters, approximately 200 words)

Detection and identification of a broad band of chemical species is a hallmark of mass spectrometry. The specific, accurate mass of ions formed in the ionization source and measured in the mass analyzer gives a mechanism for identification of the analyte. Characteristic fragmentation of the molecular species provides additional information that enhances specificity. Thus, mass spectrometry is considered one of the gold standards for identifying chemical compounds. In recent decades, the applicability of mass spectrometry has been extended to the study of large biological molecules. The advent of advanced biological mass spectrometry techniques such as electrospray ionization (ESI) and matrix assisted laser desorption/ionization (MALDI) has resulted in the ability to detect and identify large biological molecules, characteristic of many key bacterial metabolites and microorganisms such as virus, bacteria and fungi. Our team has a long history of the use of the MALDI technique coupled to miniaturized time-of-flight (TOF) mass spectrometers to create biological identifiers that move mass spectrometry out of the lab and into the field.


This effort will augment existing capability to automatically collect, process, detect and identify a wide range of biological contaminants in air, water and on surfaces. For this application, Zeteo proposes to develop the Zeteo Space Environment Microbial Monitoring System (zSEMMS) a radical redesign of existing zTADS system to meet size, weight and power (SWAP) requirements for NASA applications.  In addition to directly monitoring airborne microorganisms in the spacecraft, zSEMMS will incorporate an ability to collect and analyze water and surface samples. Because MALDI Mass Spectrometry signatures derive directly from the genome of the organism or toxin producing organism, it has outstanding specificity and sensitivity for both microorganisms and toxins.

Potential NASA Applications (Limit 1500 characters, approximately 150 words)

Primary zSEMMS application include continuous, rapid monitoring of occupied crew spaces and testing prior to occupation. The system can either be permanently installed on a spacecraft or deployed when need and removed. The sensitive nature of the instrument could also facilitate use in detecting contamination in clean rooms, laboratories or other NASA facilities in which biological contamination could put a mission at risk.

Potential Non-NASA Applications (Limit 1500 characters, approximately 150 words)

Zeteo Tech is commercializing zTADS to address critical unmet Biodefense requirements and the capabilities developed in this effort will extend zTADS to additional sample matrices. Zeteo is also developing next generation MALDI systems for rapid diagnosis of disease from breath, with a focus on pre-symptomatic detection of infectious disease.

Duration: 6

Form Generated on 06/16/2019 23:25:54