NASA SBIR 2008 Solicitation


PROPOSAL NUMBER: 08-1 X10.01-9385
SUBTOPIC TITLE: In Flight Diagnosis and Treatment
PROPOSAL TITLE: Nanoscale Test Strips for Multiplexed Blood Analysis

SMALL BUSINESS CONCERN (Firm Name, Mail Address, City/State/Zip, Phone)
The DNA Medicine Institute
116 Charles Street, Suite 6
Boston, MA 02114 - 3217
(617) 233-7656

PRINCIPAL INVESTIGATOR/PROJECT MANAGER (Name, E-mail, Mail Address, City/State/Zip, Phone)
Eugene Chan
116 Charles Street, Suite 6
Boston, MA 02114 - 3217
(617) 233-7656

Expected Technology Readiness Level (TRL) upon completion of contract: 4

TECHNICAL ABSTRACT (Limit 2000 characters, approximately 200 words)
The goal of our nanoscale test strips, or nanostrips, is to provide rapid, low-cost, powerful multiplexed analyses in a diminutive form so that whole body health checks can be performed on a single drop of blood. The approach is conceptually similar to pH or urinalysis test strips which allow multiple measurements in a linear format. The main difference is that we are proposing test strips at the nanoscale, shrunk in size over 100,000-fold in surface area, allowing multiple sensing elements to be included in a small area. The fluorescence from each element assesses the concentration of each measured analyte. In this Phase I, we will fabricate, test, and characterize test nanostrips and fabricate ones for bone metabolism. For Phase II, we will develop an entire suite of nanostrips for cardiac function, bone metabolism, liver function, lipid analysis, and hormone measurements. The nanoscale test strips are read in a time-of-flight flow-based manner utilizing our rHEALTH (Reusable Handheld Electrolytes & Lab Technology For Humans sensor) sensor, which is a low-cost, handheld sensor that employs a reusable microfluidic chip, developed with NASA funding. At the end of Phase II, the nanostrip assay suite will be delivered together with a handheld rHEALTH sensor.

POTENTIAL NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
Real-time health monitoring the proposed nanostrips are designed to monitor daily astronaut status so that adverse health events can be managed. Real-time intervention monitoring of routine health status allows rapid intervention. Measurement of bone loss during space flight via measurement of PTH, vitamin D, phosphate, calcium, N-telopeptide, and alkaline phosphatase. Liver function measurements in times of need. Measurement of cardiac biomarkers for chest pain to rule out myocardial infarction. Measurement of full body health in response to astronaut illness. Monitoring of astronaut renal function to assess volume status. Tracking of bone biomarkers and calcium levels throughout duration of missions to assess intangible bone loss and remodeling. Study of astronaut health in response to micro- and hypo-gravity environments. Study of space radiation effects on astronaut health. Measurement of astronaut fluid status in response to diets on long space trips. Systematic monitoring of astronaut health status during training on Earth.

POTENTIAL NON-NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
Real-time health monitoring development of the nanostrip panels allows monitoring of health status in real-time at the bedside or doctor's office. Real-time intervention rapid diagnosis allows immediate interventions. Measurement of acute liver damage to diagnose early hepatitis or hepatic encephalopathy. Detection of acute myocardial damage rapidly and outside the hospital so that life-saving therapy can be administered for heart attack patients. Monitoring resolution of a patient's osteoporosis with treatment so that therapy can be optimized. Monitoring daily renal function of patients with kidney transplants or those with renal disease. Measurement of athlete volume status during prolonged training for early diagnosis. Systematic measurement of lipid panels to optimize diet on more frequent intervals. Study of bone health during long journeys. Study dehydration and volume status in field personnel. Measurement of a drug's potential adverse effects on health during clinical trials. Study of myocardial damage by measuring cardiac biomarkers in hypoxic situations.

NASA's technology taxonomy has been developed by the SBIR-STTR program to disseminate awareness of proposed and awarded R/R&D in the agency. It is a listing of over 100 technologies, sorted into broad categories, of interest to NASA.

Biomolecular Sensors

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