NASA STTR 2007 Solicitation


PROPOSAL NUMBER: 07-1 T3.02-9983
RESEARCH SUBTOPIC TITLE: Bio-Technology and Life Support
PROPOSAL TITLE: An On-Chip Nano-plasmonics Based Urine Protein Assay Cartridge

NAME: CFD Research Corporation NAME: University of Pittsburgh
STREET: 215 Wynn Drive, 5th Floor STREET: 219 Parkman Avenue
CITY: Huntsville CITY: Pittsburgh
STATE/ZIP: AL  35805 - 1926 STATE/ZIP: PA  15260 - 3900
PHONE: (256) 726-4800 PHONE: (412) 624-8430

PRINCIPAL INVESTIGATOR/PROJECT MANAGER (Name, E-mail, Mail Address, City/State/Zip, Phone)
JianJun Wei
215 Wynn Drive, 5th Floor
Huntsville, AL 35805 - 1926
(256) 726-4838

Expected Technology Readiness Level (TRL) upon completion of contract: 2 to 3

TECHNICAL ABSTRACT (Limit 2000 characters, approximately 200 words)
Long-term exposure to microgravity and radiation during space exploration can pose a critical threat to the health of a flight crew. Real-time monitoring of urine protein levels is an effective way to follow the onset and progress of many diseases and guide the prompt selection of proper therapy. The success of such diagnostic tasks, which is strongly desired for flight missions, critically depends upon the degree of automation and reliability of such trace level detection. To meet this need, we propose to develop a novel on-chip, nano-plasmonic sensor cartridge to concurrently quantify the presence of different urine proteins. The envisioned device is compact, lightweight, fully integrated and automated, and highly cost- and power-effective. The program objectives will be accomplished via several innovations: (a) a new nano-plasmonics chip technology-based SPR sensor that is compatible with miniaturization, (b) tailored array modifications, allowing for concurrent screening of multiple proteins, (c) microfluidic platform for automated biochemical processes, and (d) simulation-based design for rapid prototype development. In Phase I, we will develop and demonstrate the critical microfluidic components (i.e., filter, mixer and network architecture) guided by physics-based simulations, and experimentally demonstrate the two-type-assay on a single nanoplasmonics chip for protein detection. The simulation-based design will conform to specifications that are amenable to mass-production-friendly lithographic techniques. In Phase II, the nano-plasmonic sensor will be optimized to increase sensitivity, stability, and the response to regular urine samples. Finally, the sensor will be integrated with microfluidic components and control/transmission electronics to form a portable protein assay cartridge.

POTENTIAL NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
NASA will have an on-chip nano-plasmonics based urine protein assay cartridge that can be easily integrated with existing astrobiological instrumentation to keep track of astronaut health during planetary exploration. In addition, the same device can be adapted and used in other applications such as, life discovery on other planets, pharmacotherapy environment monitoring, and space biology experiments.

POTENTIAL NON-NASA COMMERCIAL APPLICATIONS (Limit 1500 characters, approximately 150 words)
The platform developed in this effort will provide the technological backbone to develop microfluidic processing systems and nano-biosensors for a variety of applications in healthcare and the life sciences. This platform will enable the creation of analytical tools for the preparation, detection, and analysis of low abundance proteins obtained from physiological fluids and cells. It may find use in drug discovery and the study of human diseases, clinical and preclinical diagnosis, as well as in the areas of proteomics, genomics, and homeland security. Total market estimates exceed several hundred million dollars.

NASA's technology taxonomy has been developed by the SBIR-STTR program to disseminate awareness of proposed and awarded R/R&D in the agency. It is a listing of over 100 technologies, sorted into broad categories, of interest to NASA.

Biomedical and Life Support
Biomolecular Sensors
Portable Data Acquisition or Analysis Tools

Form Generated on 09-18-07 17:52